Blumea lacera has been used as a traditional medicine for anti-inflamatory, antimicrobial, anti-oxidant, anti-helminthic and diuretic. Profenofos is organgophosphate compound that generate free radical and damages the cells. In this study, profenofos (50mg/kg bw) was orally administered and 500mg/kg bw B. lacera was orally administered. Different kidney function test was performed. It was noticed that after treatment of B. lacera concentration of serum creatinine, urea and uric acid was reduced.