Diabetes mellitus is a disorder in which pancreas is unable to produce considerable amount of insulin leading to increase in blood glucose level. The International Diabetes Federation (IDF) estimated that around 15.8 million people currently in India have diabetes and will rise up to 87 million by 2030. Therefore, there is an urgent need to develop novel therapeutic agents for the treatment of diabetes, without the development and progression of complications. It is a group of disorders of carbohydrate metabolism in which the action of insulin is diminished or absent through altered secretion. It is characterized by hyperglycemia leading to severe complications. Selaginella bryopteris has various remedial properties i.e., antimicrobial, anti-inflammatory, ant-allergic, hepatoprotective and anti-apoptotic activities. Alloxan (120mg/dl) was administered intra-peritoneal to Swiss albino mice and after establishment of diabetes, aquous extract of Selaginella bryopteris (150mg/kg b.w) was orally administered for 26 day. It was noticed that Selaginella bryopteris reduces the level of glucose, increases the decreased body weight of mice and release the shrunken pancreas.