The present study is to evaluate the antimicrobial efficacy of Ribes grossularia (Grossulariaceae) against bacterial strains Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Proteus vulgaris. Aqueous, methanol and chloroform extracts of stem and leaves of R. grossularia were tested for antibacterial activity in vitro by agar well diffusion method. Highest zone of inhibition was observed in chloroform and methanol extract of stem against P. vulgaris (19.9 and 17.93mm respectively) followed by methanolic extract of stem against S. aureus (14.9 mm). Overall the methanol and chloroform extract of stem and methanol extract of leaves was found to be more effective for P. vulgaris and S. aureus. The results of this extracts were compared with standard antibiotics ampicillin, streptomycin and tetracycline.